P32: Serrated Polyposis Syndrome: A multicentre cohort study

Marine Besnard1, Elia Samaha1, Chrystel Colas2, Stanislas Chaussade3,7, Géraldine Perkins4, Pierre Laurent-Puig4,7, Yann Parc5, Jérôme Bellanger6, Sophie Grandjouan3, Christophe Cellier1,7. On behalf of PRED-IdF Network.

1 – Gastroenterology and Endoscopy Unit, Georges Pompidou European Hospital. 20 rue Leblanc, 75015 Paris. 2 – Oncogenetic department. Saint-Antoine Hospital. 184 Rue du Faubourg Saint-Antoine, 75012 Paris. 3 – Gastroenterology and Endoscopy Unit, Cochin Hospital. 27 Rue du Faubourg Saint-Jacques, 75014 Paris. 4 – Oncogenetic department, Georges Pompidou European Hospital. 20 rue Leblanc, 75015 Paris. 5 – General surgery department. Saint-Antoine Hospital. 184 Rue du Faubourg Saint-Antoine, 75012 Paris.6 – Gastroenterology and Endoscopy Unit. Saint-Antoine Hospital. 184 Rue du Faubourg Saint-Antoine, 75012 Paris.7 – Paris Descartes University, Paris

Aim

To describe the clinical and pathological features of a cohort of patients with serrated polyposis syndrome (SPS), and to assess their colorectal cancer (CRC) risk.

Method

Patients enrolled in the PRED-IdF Network who met the criteria for SPS were identified, and their features collected retrospectively.

Results

Sixty-six cases of SPS were diagnosed (WHO Criteria: I = 30%, III = 49%, I+III = 21%). The mean follow-up was 49± 47 months. The median age at diagnosis was 55 years [IQR 63-38]. A mean of 3.8± 2 colonoscopies per patient were performed, with resection of 33± 27 serrated polyps and 4± 6 adenomas per patient. Twenty-three individuals (35%) had a familial history of CRC in first-degree-relatives, and one patient had a familial history of SPS. No genetic defect was found in the cohort. Twelve CRC were diagnosed in 10 individuals (15%), at a median age of 56 years [IQR 59-31]: 1 before SPS diagnosis, 9 at the time of diagnosis, and 2 during follow-up. The cumulative risk of CRC under surveillance was 3.4% at 4 years.

Conclusion

SPS predisposes patients and their relatives to CRC, suggesting its familial pattern. A close colonoscopic surveillance is recommended.

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