Monika Morak

Monika MorakMonika Morak is a biologist and has worked as a scientist in a molecular genetics research group at the University of Munich (Klinikum der Universität München, Ludwig-Maximilians Universität) and the MGZ (Center of Medical Genetics) for 15 years, investigating genes of patients with familial gastrointestinal tumours with a special focus on Lynch syndrome.

One of her areas of expertise is the analysis of cDNA in patients suspected of having a hereditary colorectal tumour syndrome. With this method, she investigates transcription and splicing e.g. of the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in patients. Furthermore, she checks whether variants of uncertain significance such as assumed missense variants or predicted splice site defects have an effect upon mRNA splicing, which may help to evaluate their pathogenicity.