N75: Hereditary Cancer Predisposition Syndromes: Evaluation On The Influence Of Personality In Predictive Genetic Testing

L. Moreno1, T. Ocaña1, A. Sánchez1, M. Salinas2, S. Iglesias2, A. Teulé2, J. M. Peri1, F. Balaguer1

1 – Gastroenterology Department, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Spain. 2 – Institut Català d’Oncologia, Hospital Duran i Reynals, Hospitalet de Llobregat, Spain.


Aim: Assess the psychological impact of genetic testing, evaluate changes in social life and behaviour, and estimate if personality influences the use of medical resources.

Method: Ten adults undergoing predictive genetic testing for cancer predisposition syndromes were included between January and March 2017. Demographic information, personality traits, psychological distress, behaviour in some daily activities and medical resources use were collected before testing and two months after results disclosure.

Results: High pre- and post-test psychological distress was associated to low education levels, having psychopathological history, pursuing testing for offspring, and being recruited at ICO (p<0.05). It was also associated with high negative affect, detachment, psychoticism and novelty seeking, and low reward dependence, self-directiveness, cooperativeness, and persistence (p<0.05). High post-test distress was also associated with having pre-test psychological distress (p<0.05).  It would be important to know our counselees’ personality because it gives us the opportunity to know who to offer more support and how to personalize genetic counselling.

Conclusion: Our results suggest that there are some personality traits which can influence psychological distress in individuals undergoing predictive genetic testing. Further studies need to be performed in order to extrapolate these results to this particular population.