The Prospective Lynch Syndrome Database

Objectives include:

1. Prospective observations in carriers of pathogenic variants causing Lynch syndrome
2. Report prospectively observed events by observation years
3. Categorising observations by gene, gender, age and intervention(s)
4. Result publically available through open access publications
5. Results publicly available as interactive website to calculate cancer risk for any given carrier of pathogenic variant causing Lynch syndrome (www.plsd.eu)
6. Through the above arrive on empircally obtained knowledge as basis for
   • Scientific studies
   • Guidance for health care

Select links below for:

• Website
• Collaborative guidelines (PDF)
• Table structure (XLS)
• Published reports:
  • Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols
  • Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age
  • Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer
  • Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance