The Prospective Lynch Syndrome Database
- Prospective observations in carriers of pathogenic variants causing Lynch syndrome
- Report prospectively observed events by observation years
- Categorising observations by gene, gender, age and intervention(s)
- Result publically available through open access publications
- Results publicly available as interactive website to calculate cancer risk for any given carrier of pathogenic variant causing Lynch syndrome (www.plsd.eu)
- Through the above arrive on empircally obtained knowledge as basis for
- Scientific studies
- Guidance for health care
Select links below for:
- Website
- Collaborative guidelines (PDF)
- Table structure (XLS)
- Published reports:
- Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols
- Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age
- Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer
- Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance