Immunology and Pathology Working Group

Date: Friday 18 October 2019
Time: 10:30 – 12:30
Chairs: Matthias Kloor (Germany), Magnus von Knebel-Doeberitz (Germany)

Time Session
10:30 – 10:50 The mystery of beta-catenin in Lynch syndrome tumours – Hendrik Bläker
10:50 – 11:10 Immune biology of Lynch syndrome tumours – Matthias Kloor (UK)
11:10 – 11:17 Distinct immunological landscapes characterise inherited and sporadic mismatch repair deficient endometrial cancer – Neal Ramchander (UK)
11:17 – 11:24 High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer – Pauline Pfuderer (Spain)
11:24 – 11:32 Carriers of pathogenic MLH1, MSH2, and MSH6 germline variants show differences in adenoma and colorectal cancer development and molecular tumor characteristics – Christoph Engel (Germany)
11:32 – 11:39 How mathematics can help in the fight against cancer – Saskia Haupt (Germany)
11:39 – 11:46 (Epi)genetic changes in Lynch syndrome-associated adenomas with intact mismatch repair protein expression and in recurrent adenomas – Satu Mäki-Nevala (Finland)
11:46 – 11:53 Serrated neoplasia from people with SPS who carry germline RNF43 gene mutations differs in RNF43 protein expression and genome-wide DNA methylation patterns compared with idiopathic SPS cases – Eric Joo (Australia)
11:53 – 12:00 Variant profiling of colorectal adenomas from patients with MSH3-related adenomatous polyposis – Stefan Aretz (Germany)
12:00 – 12:10 Decision and future study plans
12:10 – 12:20 Closing remarks
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